CDC and FDA Must Heed Evidence on Contraindications in the Immunocompromised and Revisit Possible Vaccine-Induced Disease Enhancement

James Lyons-Weiler | 28 May 2022

Autopsies are showing higher viral load in the vaccinated, with evidence of a pathological outcome – especially in the immunocompromised.

In April, 2022, a landmark study, “High viral loads: what drives fatal cases of COVID-19 in vaccinees? – an autopsy study” was published in Modern Pathology – a Nature group journal – by Klaus Hirschbühl and colleagues.

The study found that vaccinated people who are immunocompromised are at a much higher risk of more severe COVID-19 upon infection.

The study goals were to determine the causes of death, histological organ alteration, and viral spread deceased individuals with proven SARS-CoV-2 infection after vaccination who died between January and November 2021.

The authors considered a number of factors, including demographic, clinical-pathological, viral variants, and vaccine types for twenty-nine deaths. These were compared to unvaccinated control cases.

Autopsies were only performed on a subset of (16 partially and 13 fully) vaccinated individuals. The study authors that they measured

“viral dissemination within organ systems in vaccinated cases versus nonvaccinated cases (45% vs. 16%, respectively; P = 0.008) mainly with Ct-values of higher than 25 in non-respiratory samples. However, vaccinated cases also showed high viral loads, reaching Ct-values below 10, especially in the upper airways and lungs.”

Most patients were elderly and suffered from several relevant comorbidities. Real-time RT-PCR (RT-qPCR) identified a significantly increased rate of generalized infection and higher viral loads. The authors noted that these cases also tended to have high rates of pulmonal bacterial or mycotic superinfections and the occurrence of immunocompromising factors, such as malignancies, immunosuppressive drug intake, or decreased immunoglobulin levels.

Partially vaccinated cases who died were worse off than fully vaccinated, and both the partially vaccinated and fully vaccinated were worse off than the unvaccinated.

The authors concluded:

“The virus dissemination observed in our case study may indicate that patients with an impaired immune system have a decreased ability to eliminate the virus. However, the potential role of antibody-dependent enhancement must also be ruled out in future studies. Fatal cases of COVID-19 in vaccinees were rare and often associated with severe comorbidities or other immunosuppressive conditions.”

At what point will CDC and FDA stop recommending COVID-19 vaccination for people who are immunocompromised? The data that CDC and FDA used for EUA for COVID-19 vaccines was seroconversion, not health outcomes – and those studies (like this one) found a lowered efficacy (measured by seroconversion) in the immunocompromised. Their proposed solution, of course, was boosters:

“Seroconversion rates after covid-19 vaccination were significantly lower in immunocompromised patients, especially organ transplant recipients. A second dose was associated with consistently improved seroconversion across all patient groups, albeit at a lower magnitude for organ transplant recipients. Targeted interventions for immunocompromised patients, including a third (booster) dose, should be performed.”

How that study got away with calling for third doses with no evidence on safety and efficacy is a mystery, and it speaks to the decay of the academic integrity of journals that clearly relaxed their standards to help promote the desired narrative.

Recalling this study from Germany wherein the vaccinated who died were found to have widely disseminated spike protein that could only have originated from the vaccine (“Postmortem investigation of fatalities following vaccination with COVID-19 vaccines”) – and that also found high amounts of infiltrating lymphocytes in the afflicted organs – especially in cases of VITT [vaccine-induced immune thrombotic thrombocytopenia], it is noteworthy that their results were validated by a team in Italy (See: Autopsy Findings and Causality Relationship between Death and COVID-19 Vaccination: A Systematic Review).

CDC once called one autopsy of a fetus from a woman infected with Zika virus “the strongest evidence yet” on the question of causality of the cranial and brain deformities (microcephaly) in infants born to women in the slums of Northeast Brazil – many of whom were part of a whole-cell pertussis vaccination program. This reliance on evidence labeled “strong” in support of vaccination is then dismissed as weak when the same evidence supports vaccine death and injury (See: ZIKA VS. ALUMINUM: DOUBLE STANDARDS ON LEVELS OF EVIDENCE AND MEDIA LIABILITY).

The available data support the need for VRBPC, ACIP, CDC, and FDA to revisit the question of ADE in people being vaccinated against an extinct virus (see especially Dr. Fantini’s study). It’s time our Federal legislators be tasked with demanding accountability for vaccine safety and efficacy – or better yet, replace the entire captured regime with independent scientific organizations insulated against capture.

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